TY - JOUR AU - Surikutchi, Bhanu Teja AU - Patil, Shashank Pralhad AU - Shete, Ganesh AU - Patel, Sarsvatkumar AU - Bansal, Arvind Kumar PY - 2013/09/27 TI - Drug-excipient behavior in polymeric amorphous solid dispersions JF - Journal of Excipients and Food Chemicals; Vol 4 No 3 (2013) KW - Amorphous, Solid dispersion, Miscibility, Polymeric excipients, Amorphous form stabilization, Mechanism of stabilization N2 - Amorphous drug delivery system is being increasingly utilized for enhancing aqueous solubility and oral bioavailability. However it suffers from lack of physical/chemical stability. One of the most common ways of stabilizing an amorphous form is by formulating it as amorphous solid dispersion. This review focuses on the polymeric amorphous solid dispersion wherein polymers are used as excipients to stabilize the amorphous form. We present a brief introduction of basic concepts of amorphous systems like glass transition and the solubility advantage of amorphous systems. Additionally, the paper collates information on types of polymers used for the generation of amorphous solid dispersions, their structural attributes and mechanisms of stabilization of amorphous form of drug by polymers. Molecular aspects of drug-polymer miscibility and drug-polymer interactions are also discussed. UR - https://ojs.abo.fi/ojs/index.php/jefc/article/view/214