New binary solid dispersion of Indomethacin and croscarmellose sodium: Physical characterization and in-vitro dissolution enhancement
AbstractThis article deals with the preparation of solid dispersions containing Indomethacin (IND), a poorly water-soluble drug, and the disintegrant excipient sodium croscarmellose (SC). Solid dispersions (SD) were prepared by a co-drying method and characterized by FT-IR, X-ray diffraction (XRD) and scanning electron microscopy (SEM). An FT-IR analysis performed on IND-CS solid dispersion and their physical mixtures indicated that IND does not interact with CS in the solid state. An analysis of the information produced by DSC, XRD, and SEM provided confirmation that the crystalline ?-form of IND was homogeneously incorporated into SD. IND release from SD was substantially higher than that from physical mixtures with the high homogeneous molecular dispersion and the crystalline modification of IND appearing the cause. This behavior may have a beneficial effect on the biopharmaceutical performance of this drug.
How to Cite
CASTRO, Silvina et al. New binary solid dispersion of Indomethacin and croscarmellose sodium: Physical characterization and in-vitro dissolution enhancement. Journal of Excipients and Food Chemicals, [S.l.], v. 3, n. 4, p. 121-128, dec. 2012. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/150>. Date accessed: 29 nov. 2023.
Original Research Articles
Solid dispersions, Croscarmellose sodium; Indomethacin; Dissolution rate,;Solid state characterization; Co-processed material.
Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).