New binary solid dispersion of Indomethacin and croscarmellose sodium: Physical characterization and in-vitro dissolution enhancement

  • Silvina Castro
  • María Veronica Ramírez-Rigo Planta Piloto de Ingeniería Química
  • Daniel Allemandi
  • Santiago Palma

Abstract

This article deals with the preparation of solid dispersions containing Indomethacin (IND), a poorly water-soluble drug, and the disintegrant excipient sodium croscarmellose (SC). Solid dispersions (SD) were prepared by a co-drying method and characterized by FT-IR, X-ray diffraction (XRD) and scanning electron microscopy (SEM). An FT-IR analysis performed on IND-CS solid dispersion and their physical mixtures indicated that IND does not interact with CS in the solid state. An analysis of the information produced by DSC, XRD, and SEM provided confirmation that the crystalline ?-form of IND was homogeneously incorporated into SD. IND release from SD was substantially higher than that from physical mixtures with the high homogeneous molecular dispersion and the crystalline modification of IND appearing the cause. This behavior may have a beneficial effect on the biopharmaceutical performance of this drug.
Published
2012-12-19
How to Cite
CASTRO, Silvina et al. New binary solid dispersion of Indomethacin and croscarmellose sodium: Physical characterization and in-vitro dissolution enhancement. Journal of Excipients and Food Chemicals, [S.l.], v. 3, n. 4, p. 121-128, dec. 2012. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/150>. Date accessed: 24 apr. 2019.
Section
Original Research Articles

Keywords

Solid dispersions, Croscarmellose sodium; Indomethacin; Dissolution rate,;Solid state characterization; Co-processed material.