Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, II: Cellulosic polymers

  • Anuprabha Meena St. John's University
  • Tapan Parikh St. John's University
  • Simerdeep Singh Gupta St. John's University
  • Abu T. M. Serajuddin St.John's University, New York

Abstract

The purpose of the study was to evaluate the thermal and viscoelastic properties of cellulosic polymers commonly used in hot melt extrusion (HME). Cellulose ethers of different molecular weight (MW) with varied degree of substitution and functional groups were analyzed using modulated differential scanning calorimetry (MDSC), thermogravimetric analysis (TGA) and oscillatory rheometry. The results indicate that glass transition temperature (Tg) and viscoelastic characteristics of polymers strongly depend on their chain length, MW, and degree and type of substitutions in the main chain. In general, an increase in chain length or MW was found to increase Tg as well as the viscosity (HPMC, MW10000 < MW 25000 < MW 150000). Also, substitutions with bulkier groups decrease the Tg and viscosity of the polymer. Most of the cellulosics were found to have high viscosity between their Tg and degradation temperature (Td), and thus cannot be extruded by themselves. The thermal properties in combination with polymer viscosity at different temperature will help formulators determine processability using HME.

Published
2014-03-31
How to Cite
MEENA, Anuprabha et al. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, II: Cellulosic polymers. Journal of Excipients and Food Chemicals, [S.l.], v. 5, n. 1, p. 46-55, mar. 2014. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/345>. Date accessed: 19 oct. 2021.
Section
Original Research Articles

Keywords

Cellulose, HPMC, HPMC-AS, HPMCP, thermal properties, Tg, rheology, viscosity, polymers, hot melt extrusion