Understanding the implications of pharmaceutical excipients and additives in the treatment of diabetic foot ulcers

  • V V S Narayana Reddy Karri Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS University, Mysore, India.
  • Gowthamarajan Kuppusamy Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS University, Mysore, India.
  • Shashank Mulukutla Department of Pharmacology, JSS College of Pharmacy, Ootacamund, JSS University, Mysore, India.
  • Sumeet Sood Scientific writing, Indegene lifesystems pvt ltd, Manyata tech park, Bengaluru, India.
  • Rajkumar Malayandi Pharmacokinetic Research and Development, Sun Pharmaceutical Industries Ltd, Part Survey No. 27 C.S No.1050, Village Tandalja, Baroda, India.

Abstract

A diabetic foot ulcer (DFUs) is a consequence of Diabetes Mellitus (DM) and involves complex pathological processes. It is a major cause of deaths among diabetic patients as a result of amputations. Various treatment strategies have been developed for the treatment of DFUs; unfortunately no single treatment will fulfill the prerequisites necessary for treating DFUs due to its complexed, multifactorial pathophysiology and also the overall cost of these treatments are high. Excipients are the pharmaceutical agents which have diverse applications in the design of different dosage forms. Hence, an ideal dosage form, with active excipients in combination or as adjuvants, which meets these requirements would probably best suited for treating DFUs. This review discusses the etiopathogenesis of DFUs and also the possible use of excipients and additives on various pathological cases of DFUs in designing products intended for the treatment of DFUs.

Author Biographies

V V S Narayana Reddy Karri, Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS University, Mysore, India.
Department of Pharmaceutics
Shashank Mulukutla, Department of Pharmacology, JSS College of Pharmacy, Ootacamund, JSS University, Mysore, India.
Department of Pharmacology
Sumeet Sood, Scientific writing, Indegene lifesystems pvt ltd, Manyata tech park, Bengaluru, India.
Scientific writing
Rajkumar Malayandi, Pharmacokinetic Research and Development, Sun Pharmaceutical Industries Ltd, Part Survey No. 27 C.S No.1050, Village Tandalja, Baroda, India.
Pharmacokinetic Research and Development
Published
2015-03-30
How to Cite
KARRI, V V S Narayana Reddy et al. Understanding the implications of pharmaceutical excipients and additives in the treatment of diabetic foot ulcers. Journal of Excipients and Food Chemicals, [S.l.], v. 6, n. 1, p. 7-22, mar. 2015. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/905>. Date accessed: 27 oct. 2021.
Section
Reviews

Keywords

Excipients; additives; diabetes; diabetic foot ulcer; diabetic wound; chronic wound.