Development of Solid SEDDS: III. Application of Acconon C-50 and Gelucire 50/13 as Both Solidifying and Emulsifying Agents for Medium Chain Triglycerides

  • Abu T. M. Serajuddin Professor

Abstract

Solid self-emulsifying drug delivery systems (SEDDS) for medium chain triglycerides (Captex 355, ABITEC) were developed using stearoyl polyoxyl glycerides (Acconon C-50, ABITEC and Gelucire 50/13, Gattefosse) as both solidifying and emulsifying agents. Different mixtures of the lipid and each solidifying agent were heated to 65C until homogenously mixed clear liquids were formed. Probucol was dissolved as the model drug. The molten mass was then filled in hard gelatin capsules, which formed solid mass upon cooling to room temperature. The triglyceride could be incorporated in the system to a concentration as high as 80% w/w by still maintaining the solid consistency of the system. Powder XRD, DSC, microscopy (cross-polarization and confocal fluorescence techniques), dispersion test, and particle size analysis of the solid systems with and without drug were conducted to characterize different formulations. The solidifying agents maintained their crystallinity in solid systems, while the lipids were interspersed in between crystalline regions. The drug remained solubilized in the lipid phase. The formulations dispersed almost completely in 2 h with particle size of the dispersed lipid in the range of 250 to 500 nm when the lipid content in the formulation was up to 50% w/w. Thus, a novel method of developing solid formulations of liquid triglycerides by incorporating lipids in stearoyl polyoxylglycerides has been developed.

Author Biography

Abu T. M. Serajuddin, Professor
Abu Serajuddin, Ph.D., is a Professor of Industrial Pharmacy at St. Johns University, Queens, New York, USA. At St. Johns, he is building active research programs and centers of excellence in drug delivery sciences and pharmaceutical processing technologies. One focus of his research is identification and characterization of polymeric and lipidic carriers for developing bioavailable oral dosage forms of poorly water-soluble drugs. Prior to joining academia in September 2008, he worked in the pharmaceutical industry for three decades with increasing scientific and managerial responsibilities at Sanofi-Aventis (through mergers), Bristol-Myers Squibb and Novartis. In his latest positions in the industry, Dr. Serajuddin served as Executive Director and the US Head of Drug Product Development (1999-2003) and the Global Head of Science and Technology Development (2003-2008) for Novartis Pharmaceuticals Corp. In recognition of his extraordinary scientific achievements, he was named a Novartis Leading Scientist in 2005. He contributed extensively to basic pharmaceutics and drug delivery systems. He authored over 75 research papers and book chapters and made 80 invited presentations in major scientific conferences (US, France and China). He is a co-inventor in 14 patents, the majority of the patents being on drug delivery technology platforms. Among his professional recognitions, he attained Fellow status in American Association of Pharmaceutical Scientists (AAPS), American Pharmacists Association (APhA), International Union of Pure and Applied Chemistry (IUPAC), and American Association of Indian Pharmaceutical Scientists (AAiPS). He serves in the Editorial Advisory Board s of Journal of Pharmaceutical Sciences and Journal of Excipients and Food Chemicals. Among his many professional contributions, he chaired AAPS Pharmaceutics and Drug Delivery Section (2001) and AAPS Preformulation Focus Group (1994-1996). A graduate in pharmacy from Dhaka University, Bangladesh, Serajuddin received his Ph.D. in Industrial Pharmacy from St. John's University, New York, M.S. in Pharmaceutics from Columbia University, New York, and Advanced Training in Industrial Pharmacy from the University of Pisa, Italy.
Published
2012-06-20
How to Cite
SERAJUDDIN, Abu T. M.. Development of Solid SEDDS: III. Application of Acconon C-50 and Gelucire 50/13 as Both Solidifying and Emulsifying Agents for Medium Chain Triglycerides. Journal of Excipients and Food Chemicals, [S.l.], v. 3, n. 2, p. 83-92, june 2012. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/142>. Date accessed: 28 oct. 2021.
Section
Original Research Articles

Keywords

Self-emulsifying system; solid formulation; lipid; surfactant; solidifying agent; Acconon C-50; Gelucire 50/13; dispersion test; particle size