Interaction of Resveratrol analogues with biomembrane models: A calorimetric study on structural variations effects.

  • Francesco Castelli Dipartimento di Scienze del Farmaco

Abstract

Differential Scanning Calorimetry was employed to study the interaction of new resveratrol derivatives with dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLV), used as biomembrane models. MLV prepared in the presence of increasing molar fractions of 3,5,3,5-tetramethoxystilbene (1) 3,5,3,4-tetramethoxystilbene (2) 3,4,5,4-tetramethoxystilbene (3) 3,4,5, 3,5-pentamethoxystilbene (4) and 3,4,2,4,5-pentamethoxystilbene (5) were analyzed to study the effects exerted by number and position of substituents on the variations of thermotropic properties of biomembrane models. The experimental results showed that the number and the position of substituent strongly affected the interaction between compounds and DMPC MLV. The kinetic experiments demonstrate that in an aqueous medium the absorption of 1 - 5 is hindered whereas the presence of a lipophilic medium improves the absorption of compounds by biomembrane models.
Published
2012-09-21
How to Cite
CASTELLI, Francesco. Interaction of Resveratrol analogues with biomembrane models: A calorimetric study on structural variations effects.. Journal of Excipients and Food Chemicals, [S.l.], v. 3, n. 3, p. 96-105, sep. 2012. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/155>. Date accessed: 24 oct. 2021.
Section
Original Research Articles

Keywords

: resveratrol; resveratrol derivative; DSC; liposome; biomembrane model