Interaction of Resveratrol analogues with biomembrane models: A calorimetric study on structural variations effects.
Abstract
Differential Scanning Calorimetry was employed to study the interaction of new resveratrol derivatives with dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLV), used as biomembrane models. MLV prepared in the presence of increasing molar fractions of 3,5,3,5-tetramethoxystilbene (1) 3,5,3,4-tetramethoxystilbene (2) 3,4,5,4-tetramethoxystilbene (3) 3,4,5, 3,5-pentamethoxystilbene (4) and 3,4,2,4,5-pentamethoxystilbene (5) were analyzed to study the effects exerted by number and position of substituents on the variations of thermotropic properties of biomembrane models. The experimental results showed that the number and the position of substituent strongly affected the interaction between compounds and DMPC MLV. The kinetic experiments demonstrate that in an aqueous medium the absorption of 1 - 5 is hindered whereas the presence of a lipophilic medium improves the absorption of compounds by biomembrane models.
Published
2012-09-21
How to Cite
CASTELLI, Francesco.
Interaction of Resveratrol analogues with biomembrane models: A calorimetric study on structural variations effects..
Journal of Excipients and Food Chemicals, [S.l.], v. 3, n. 3, p. 96-105, sep. 2012.
ISSN 21502668.
Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/155>. Date accessed: 22 dec. 2024.
Issue
Section
Original Research Articles
Keywords
: resveratrol; resveratrol derivative; DSC; liposome; biomembrane model
Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
