Development and Evaluation of a Novel, Multifunctional, Co-processed Excipient via Roll Compaction of α- Lactose Monohydrate and Magnesium Silicate

  • Faisal Al-Akayleh Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
  • Mohammed Shubair Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
  • Hatim AlKhatib Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman, Jordan
  • Iyad Rashid The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan
  • Adnan Badwan The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan
  • Mustafa AL-Mishlab Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan

Abstract

Abstract

Co-processing of lactose with synthetic amorphous magnesium silicate has been investigated herein in the context of expanding native lactose applications as a direct compressible excipient. The foregoing was carried out using roll compactor. The obtained excipient was characterized using particle size analysis and compression properties (Kawakita equation). This new excipient showed plastic behavior upon compression, good flowability and crushing strength with shorter disintegration time. Compatibility was tested by differential scanning calorimetry (DSC) and FTIR. The interaction between lactose and Mg silicate proved to be of a physical nature. Formulation with this processed excipient on Mebeverine HCl and Losartan Potassium as model drugs indicated its suitability to be used as a single multifunctional excipient. As a result coprocessed lactose with Mg silicate can be used as a single direct compressible excipient for tablet manufacturing.


Author Biographies

Faisal Al-Akayleh, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
Mohammed Shubair, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
Hatim AlKhatib, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman, Jordan
Iyad Rashid, The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan
Adnan Badwan, The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan
Mustafa AL-Mishlab, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
Published
2013-06-27
How to Cite
AL-AKAYLEH, Faisal et al. Development and Evaluation of a Novel, Multifunctional, Co-processed Excipient via Roll Compaction of α- Lactose Monohydrate and Magnesium Silicate. Journal of Excipients and Food Chemicals, [S.l.], v. 4, n. 2, p. 27-37, june 2013. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/202>. Date accessed: 24 oct. 2021.
Section
Original Research Articles

Keywords

Co - processed excipient; Lactose; Magnesium Silicate; Direct Compression Excipient; Roller Compaction.