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Faisal Al-Akayleh
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
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Mohammed Shubair
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
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Hatim AlKhatib
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman, Jordan
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Iyad Rashid
The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan
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Adnan Badwan
The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan
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Mustafa AL-Mishlab
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
Abstract
Abstract
Co-processing of lactose with synthetic amorphous magnesium silicate has been investigated herein in the context of expanding native lactose applications as a direct compressible excipient. The foregoing was carried out using roll compactor. The obtained excipient was characterized using particle size analysis and compression properties (Kawakita equation). This new excipient showed plastic behavior upon compression, good flowability and crushing strength with shorter disintegration time. Compatibility was tested by differential scanning calorimetry (DSC) and FTIR. The interaction between lactose and Mg silicate proved to be of a physical nature. Formulation with this processed excipient on Mebeverine HCl and Losartan Potassium as model drugs indicated its suitability to be used as a single multifunctional excipient. As a result coprocessed lactose with Mg silicate can be used as a single direct compressible excipient for tablet manufacturing.
Author Biographies
Faisal Al-Akayleh, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
Mohammed Shubair, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
Hatim AlKhatib, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman, Jordan
Iyad Rashid, The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan
Adnan Badwan, The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan
Mustafa AL-Mishlab, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan
Section
Original Research Articles
Keywords
Co - processed excipient; Lactose; Magnesium Silicate; Direct Compression Excipient; Roller Compaction.
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