Application of Excipient Made from Chitosan - Xanthan as a Single Component for the Controlled Release of Ambroxol Tablet

  • Mayyas Al Remawia Department of pharmaceutics and pharmaceutical technology, College of Pharmacy, Taif University, Taif, Saudi Arabia
  • Faisal Al-Akayleh Department of pharmaceutics and pharmaceutical technology, College of Pharmacy, Petra University, Amman, Jordan
  • Mutaz Salem Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
  • Munther Al Shami Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
  • Adnan Badwan Suwagh company for drug delivery systems subsidiary of the Jordanian Pharmaceutical Manufacturing Company (JPM), Naor, Jordan

Abstract

Abstract

Oral controlled release (CR) matrix system of Ambroxol HCl was developed using binary hydrophilic polymer mixture of chitosan (CH) and xanthan gum (XG). Drug to polymer ratios (D: P) tested were 1:1 and 1:3 (w/w). The in-vitro drug release data was best fitted to Higuchi equation. The 1:1 ratio showed in-vitro dissolution similarity with the commercial product, Mucosolvan LA ®. The in-vivo release study was conducted on six volunteers.  The data showed that the D: P (1:1) ratio is bioequivalent to Mucosolvan  LA ® after the administration of a single oral dose under fasting conditions. Two in-vivo in-vitro correlations (IVIVC) were established between Cmax versus fraction of drug dissolved (FRD) after 4 h, and AUC versus ratio of fraction of drug dissolved (FRD) after 10 h where a multiple C level of IVIVC was obtained.

Published
2013-06-27
How to Cite
AL REMAWIA, Mayyas et al. Application of Excipient Made from Chitosan - Xanthan as a Single Component for the Controlled Release of Ambroxol Tablet. Journal of Excipients and Food Chemicals, [S.l.], v. 4, n. 2, p. 48-57, june 2013. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/203>. Date accessed: 24 oct. 2021.
Section
Original Research Articles

Keywords

Ambroxol HCl; Xanthan gum; Chitosan; Controlled release; Bioequivalence