Grewia polysaccharide as a pharmaceutical excipient in matrix tablets

  • Elijah I. Nep
  • Barbara R. Conway

Abstract

Matrix-based tablets using different concentrations of grewia gum and the model drug, ibuprofen, were prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum or ethyl cellulose as the polymer matrix. In addition to tablet properties, swelling and erosion of tablets and kinetics of drug release were also investigated. In vitro dug release studies, in phosphate buffer (pH 7.2) using USP type II apparatus, revealed that grewia gum at concentrations of 16 %, 32 % and 48 % can sustain the release of ibuprofen tablets for up to 24 hours. Release profiles were similar to those tablets containing ethyl cellulose as the matrix former. Swelling and erosion of grewia gum matrices occurred simultaneously, and ibuprofen release was by anomalous diffusion in accordance with Korsmeyer-Peppas model. There was evidence suggesting synergism between grewia gum and guar gum in sustaining the release of ibuprofen from tablets when used in the ratio 2:1 and grewia gum may therefore prove a useful excipient when used on its own, or in combination with other polymers, to modify drug release.

Author Biographies

Elijah I. Nep
Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET Present address: Department of Pharmaceutics and Pharm. Technology, University of Jos, Nigeria. Corresponding author. Tel.: +2348166116714 Email address: nepeli2000@yahoo.com
Barbara R. Conway
Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET Present address: Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH Tel: +44(0)1484 472347 Email address: B.R.Conway@hud.ac.uk
Published
2011-03-23
How to Cite
NEP, Elijah I.; CONWAY, Barbara R.. Grewia polysaccharide as a pharmaceutical excipient in matrix tablets. Journal of Excipients and Food Chemicals, [S.l.], v. 2, n. 1, p. 3-15, mar. 2011. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/46>. Date accessed: 24 oct. 2021.
Section
Original Research Articles

Keywords

Ibuprofen, swelling, erosion, drug release, release profile, controlled delivery