In vitro / in vivo evaluation of procera gum-ethylcellulose microspheres for colonic delivery of budesonide

  • Lalduhsanga Pachuau Regional Institute of Paramedical and Nursing Sciences
  • Bhaskar Mazumder Department of Pharmaceutical Sciences, Dibrugarh University, Assam - 786004.

Abstract

The objective of the present research was to develop colonic delivery system for budesonide based on polymer blends of natural polysaccharides from Albizia procera and GI insoluble polymer ethylcellulose. Emulsion solvent evaporation method was followed for preparation of the microspheres. In vitro drug release was studied on a medium simulating gastrointestinal fluid and mechanism of drug release was determined by Korsemeyer-Peppas equation. In vivo performance of the microsphere was evaluated on acetic acid induced colitis in rats. Drug release studies showed microspheres from procera gum-ethylcellulose coating was able to resist premature drug release in the upper GI tract and susceptible to enzyme effects in the colon. Treatment of rats with budesonide test formulation for five days also significantly attenuated the extent and severity of the cell damage and is a promising system for treatment of ulcerative colitis.

Author Biographies

Lalduhsanga Pachuau, Regional Institute of Paramedical and Nursing Sciences
Department of Pharmacy, Assistant Professor
Bhaskar Mazumder, Department of Pharmaceutical Sciences, Dibrugarh University, Assam - 786004.
Department of Pharmaceutical Sciences & Assistant Professor
Published
2014-09-18
How to Cite
PACHUAU, Lalduhsanga; MAZUMDER, Bhaskar. In vitro / in vivo evaluation of procera gum-ethylcellulose microspheres for colonic delivery of budesonide. Journal of Excipients and Food Chemicals, [S.l.], v. 5, n. 3, p. 161-172, sep. 2014. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/817>. Date accessed: 24 oct. 2021.
Section
Original Research Articles

Keywords

Colon drug delivery; Albizia procera; Ethylcellulose; Polymer blends; Ulcerative colitis