CHARACTERIZATION OF GREWIA GUM, A POTENTIAL PHARMACEUTICAL EXCIPIENT
AbstractGrewia gum was extracted from the inner stem bark of Grewia mollis and characterized by several techniques such as gas chromatography (GC), gel permeation chromatography (GPC), scanning electron microscopy (SEM), dilute solution viscometry, differential scanning calorimetry (DSC) and thermogrametric analysis of the extracted samples. Spectroscopic techniques such as x-ray photoelectron spectroscopy (XPS), fourier-transformed infrared (FT-IR), solid-state nuclear magnetic resonance (NMR), and 1H and 13C NMR techniques were also used to characterize the gum. The results showed that grewia gum is a typically amorphous polysaccharide gum containing glucose, rhamnose, galactose, arabinose and xylose as neutral sugars. It has an intrinsic viscosity of 48.36 0.37 dl/g and an average molecular weight of 5925 kDa expressed as the pullulan equivalent. The gum slowly hydrated in water, dispersing and swelling to form a highly viscous dispersion exhibiting pseudoplastic flow behaviour. The polysaccharide gum is thermally stable and may have application as stabilizer or suspending agent in foods, cosmetics and in pharmaceuticals. It may have application as a binder or sustained-release polymer matrix in tablets or granulations.
How to Cite
NEP, Elijah I.; CONWAY, Barbara R.. CHARACTERIZATION OF GREWIA GUM, A POTENTIAL PHARMACEUTICAL EXCIPIENT. Journal of Excipients and Food Chemicals, [S.l.], v. 1, n. 1, p. 30-40, june 2010. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/12>. Date accessed: 02 july 2022.
Original Research Articles
grewia gum, extraction, polysaccharide, pseudoplastic flow, suspending agent, binder, sustained release.
Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).