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Narayan Babulal Gaikwad
Research Scholar,Department of Pharmaceutics,Karpagam University,Coimbatore,TN,India
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Giriraj Kulkarni
Professor & Principal, Laureate College of Pharmacy, Kathog, Teh-Dehra, Dist-Kangra, Himachal Pradesh, India
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Gowthamarajan K
Professor & Head, Department of Pharmaceutics, JSS college of Pharmacy, Ooty, Tamilnadu, India
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E P Kumar
Professor & Dean, Department of Pharmacy, Karpagam University, Coimbatore, Tamilnadu, India
Abstract
Gum was isolated from the the bark of Buchanania cochinchinesis (Family: Anacadiacea) and was used as a release modifier for the preparation of Diclofenac sodium spheroids, using the extrusion spheronization technique. The process was studied for the effect of variables to arrive at spheroids with satisfactory particle shape, size and size distribution. The prepared spheroids were characterized for surface morphology, qualitative surface porosity, friability, bulk density and flow properties. The in vitro release studies exhibited a first order release kinetics that were confirmed by Higuchis and Peppas models. A credible correlation was obtained physico-chemical parameters of gum and in vitro dissolution profile of the spheroids. In the comparative study we found that the developed spheroids were not able to sustain the drug releases over 12 hours. A greater concentration of Chirauli nut gum may produce a formulation capable of significant sustained release.
Section
Original Research Articles
Keywords
Spheroids, Buchanania cochinchinesis, extrusion-spheronization, gum, Higuchi, Peppas
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