Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Petra University, Amman, Jordan
Mayyas Al Remawi
Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Taif, Saudi Arabia
Mutaz S. Salem
Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
Current address Royal University for Medical Sciences, Amman, Jordan
Suwagh Company for Drug Delivery Systems Subsidiary of the Jordanian Pharmaceutical Manufacturing Company (JPM), Naor, Jordan
Directly compressed matrices were produced using binary mixture of different chitosan (CH) and xanthan gum (XG) ratios. These hydrophilic excipients were used to control the release of ambroxol HCl. Three CH to XG ratios were investigated namely: 1:1, 1:4 and 4:1. Mucosolvan LA® was used as a reference commercial product. The optimal CH to XG ratio was 1:1 and the optimal drug to polymer mixture ratio was 1:3. Matrix erosion, hydration and drug release study were carried out using a dissolution apparatus (basket method). The mechanism of release was discussed.
How to Cite
AL-AKAYLEH, Faisal et al.
Chitosan and Xanthan Gum Mixtures as Excipient for Controlled Release of Ambroxol HCl: In- vitro drug Release and Swelling Behavior.
Journal of Excipients and Food Chemicals
, [S.l.], v. 5, n. 2, p. 140-148, june 2014.
Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/267
>. Date accessed: 28 oct. 2021.
Original Research Articles
Ambroxol HCl; Xanthan gum; Chitosan; Controlled release; Swelling
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