Chitosan and Xanthan Gum Mixtures as Excipient for Controlled Release of Ambroxol HCl: In- vitro drug Release and Swelling Behavior

  • Faisal Al-Akayleh Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Petra University, Amman, Jordan
  • Mayyas Al Remawi Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Taif, Saudi Arabia
  • Mutaz S. Salem Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan Current address Royal University for Medical Sciences, Amman, Jordan
  • Adnan Badwan Suwagh Company for Drug Delivery Systems Subsidiary of the Jordanian Pharmaceutical Manufacturing Company (JPM), Naor, Jordan

Abstract

Abstract

 

Directly compressed matrices were produced using binary mixture of different chitosan (CH) and xanthan gum (XG) ratios. These hydrophilic excipients were used to control the release of ambroxol HCl. Three CH to XG ratios were investigated namely: 1:1, 1:4 and 4:1. Mucosolvan LA® was used as a reference commercial product.  The optimal CH to XG ratio was 1:1 and the optimal drug to polymer mixture ratio was 1:3. Matrix erosion, hydration and drug release study were carried out using a dissolution apparatus (basket method). The mechanism of release was discussed.

Published
2014-06-25
How to Cite
AL-AKAYLEH, Faisal et al. Chitosan and Xanthan Gum Mixtures as Excipient for Controlled Release of Ambroxol HCl: In- vitro drug Release and Swelling Behavior. Journal of Excipients and Food Chemicals, [S.l.], v. 5, n. 2, p. 140-148, june 2014. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/267>. Date accessed: 28 oct. 2021.
Section
Original Research Articles

Keywords

Ambroxol HCl; Xanthan gum; Chitosan; Controlled release; Swelling