STUDIES ON EFFECT OF PLASTICIZER ON INVITRO RELEASE AND EXVIVO PERMEATION FROM EUDRAGIT E100 BASED CHLORPHENIRAMINE MALEATE MATRIX TYPE TRANSDERMAL DELIVERY SYSTEM

  • Rajan Rajabalaya International Medical University

Abstract

The release and permeation studies were carried out for developing transdermal therapeutic systems with chlorpheniramine maleate (CPM). The patches were prepared with Eudragit E100 with/without polyvinyl pyrrolidone (PVP) and dibutyl phthalate (DBP) as well as dibutyl sebacate (DBS) as the plasticizer in different compositions. Thickness, tensile strength, modulus of elasticity, drug content, moisture content and water absorption studies of the patches were measured. In vitro release/permeation of CPM was studied in modified Keshary-Chien diffusion cell. Chemical enhancers like l-menthol, oleic acid and phospholipon80 were added to compare the release pattern of the drug. The percent release of the drug from matrix patch increased with the increase of PVP & plasticizers but the tensile strength decreased. Experimental release/permeation data of different formulations of the matrix systems are reported. Also the drug-polymer interaction was investigated by ATR-FTIR studies. This study reports that the suitable plasticizer & chemical enhancers for Eudragit E 100 polymer for controlled release/permeation of CPM; hence this drug could be a potential candidate for transdermal antihistamine & wound healing applications in film device industry.

Author Biography

Rajan Rajabalaya, International Medical University
Lecturer, School of Pharmacy International Medical University, No. 126, Jalan 19/155B, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
Published
2010-09-16
How to Cite
RAJABALAYA, Rajan. STUDIES ON EFFECT OF PLASTICIZER ON INVITRO RELEASE AND EXVIVO PERMEATION FROM EUDRAGIT E100 BASED CHLORPHENIRAMINE MALEATE MATRIX TYPE TRANSDERMAL DELIVERY SYSTEM. Journal of Excipients and Food Chemicals, [S.l.], v. 1, n. 2, p. 3-12, sep. 2010. ISSN 21502668. Available at: <https://ojs.abo.fi/ojs/index.php/jefc/article/view/6>. Date accessed: 07 dec. 2021.
Section
Original Research Articles

Keywords

Chlorpheniramine maleate; Eudragit polymer; Polyvinyl pyrrolidone; Dibutyl phthalate; Dibutyl sebacate; Chemical enhancers.